CUCURBITACIN B

Product Name: CUCURBITACIN B
CAS No.: 6199-67-3
Chemical Name: CUCURBITACIN B
Synonyms: Cuc B;AMARINE;HSDB 3476;DATISCACIN;NSC-144154;heMsecin A;Cucurbitacin;cucuritacin B;cucurbitacineb;CUCURBITACIN B
CBNumber: CB5113260
Molecular Formula: C32H46O8
Formula Weight: 558.7
MOL File: 6199-67-3.mol

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CUCURBITACIN B Property

Melting point:: 184-186°
alpha: D25 +88° (c = 1.55 in ethanol)
Boiling point:: 546.74°C (rough estimate)
Density: 1.0953 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 12.60±0.29(Predicted)
color: white to beige
λmax: 290nm(EtOH)(lit.)
Merck: 14,2614
Stability:: Hygroscopic
InChIKey: IXQKXEUSCPEQRD-ALLWXVAWSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45-24/25
RIDADR: UN 2811 6.1 / PGI
WGK Germany: 3
RTECS: RC6190000
HazardClass: 6.1
PackingGroup: II
HS Code: 29153900
Hazardous Substances Data: 6199-67-3(Hazardous Substances Data)
Toxicity: LD10 orally in mice: 5 mg/kg (LeMen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8499
Product name: Cucurbitacin B hydrate
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $256
Updated: 2024/03/01

Sigma-Aldrich

Product number: C8499
Product name: Cucurbitacin B hydrate
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $1020
Updated: 2024/03/01

TCI Chemical

Product number: C3442
Product name: Cucurbitacin B
Purity: >98.0%(HPLC)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

TCI Chemical

Product number: C3442
Product name: Cucurbitacin B
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $478
Updated: 2024/03/01

Cayman Chemical

Product number: 14820
Product name: Cucurbitacin B
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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CUCURBITACIN B Chemical Properties,Usage,Production

Description

Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.

Chemical Properties

White solid

Uses

Cucurbitacin B hydrate has been used:

as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
to determine its effect on the cell viability of pancreatic cancer cell lines.

Definition

ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.

Biochem/physiol Actions

Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.

CUCURBITACIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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CUCURBITACIN B Suppliers

Americas 1 China 229 Europe 1 India 2 Japan 1 United Kingdom 3 United States 22 USA 1 Global 260

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
Advantage: 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

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View Lastest Price from CUCURBITACIN B manufacturers

Henan Fengda Chemical Co., Ltd

Product: CUCURBITACIN B 6199-67-3
Price: US $8.00-0.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Hebei Yanxi Chemical Co., Ltd.

Product: Cucurbitacin B 6199-67-3
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cucurbitacin B 6199-67-3
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: Cucurbitacin B≥60%
Supply Ability: 500kg
Release date: 2021-12-13

6199-67-3, CUCURBITACIN BRelated Search:

CUCURBITACIN D,CUCURBITACIN D WITH HPLC CUCURBITACIN E(SH),CUCURBITACIN E,CUCURBITACIN E hplc,CUCURBITACIN E WITH HPLC 24-epi-Cucurbitacin G,Cucurbitacin G,Cucurbitacin H Cucurbitacin A Cucurbitacin F Cucurbitacin L dihydrocucurbitacin F Calebassine Cucurbitacin Ia,Cucurbitacin F-25-acetate CUCURBITACIN B 4-TERT-PENTYLCYCLOHEXANONE 4-tert-Butylcyclohexanone CUCURBITACIN D(SH) Cucurbitacin C Cucurbitacin IIb CUCURBITACIN IIA CUCURBITACIN I WITH HPLC,Cucurbitacin I hydrate,CUCURBITACIN I hplc,CUCURBITACIN I(SH),CUCURBITACIN I (E,Z)-2,13-OCTADECADIENOL

(2beta,9beta,10alpha,16alpha,23e)-thyl

19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25

19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet

19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me

25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr

Cucurbitacin B hydrate

Cucurbitacin B, 98%, from Cucumis melo L.

cucurbitacineb

AMARINE

1,2-DIHYDRO-ALPHA-ELATERIN

CUCURBITACIN B

DATISCACIN

Dihydrocucurbitacin F-25-acetate

Cucurbitacin

HSDB 3476

CUCURBITACIN B(RG)

(23E)-25-(Acetyloxy)-2β,16α,20-trihydroxycucurbita-5,23-diene-3,11,22-trione

(9β,10α,23E)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione

NSC-144154

Cucurbitacin B ,97%

CUCURBITACIN B(P)

heMsecin A

Cucurbitacin B, froM CucuMis Melo

(2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione

Cucurbitacin B, >99%

Cucurbitacin B, 98%, from Cucumis melo

BCucurbitacin B

Cuc B

19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-

CUCURBITACIN B USP/EP/BP

CAS?6199-67-3?Combretastatin A4 (Z) -Combretastatin A4 CAS 117048-59-6

cucuritacin B

(+)-Cucurbitacin B

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

6199-67-3

C32H46O8

Tri-Terpenoids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract